Friday, September 26, 2008

Stems Cells from Mature parents

Scientists have found a way to convert mature cells into an embryonic-like state that could eliminate an earlier method's risk of triggering cancer, potentially overcoming a big hurdle in the quest to develop new transplant therapies.

Though demonstrated only in mice so far, the result marks another key achievement in the fledgling science of cellular reprogramming. The hope is to create human, embryonic-like stem cells -- which can be turned into all the other tissue types of the body -- without using eggs or destroying embryos. That freshly derived tissue could then be transplanted into patients to treat various diseases.

Progress has been brisk. In 2006, Japanese researchers first showed that four genes inserted into the mature skin cell of a mouse were enough to return the cell to a primordial, embryonic-like state. Several groups of scientists have since achieved the same result with human cells.

More recent experiments have shown that fresh tissue derived in this manner can alleviate the symptoms of Parkinson's disease and sickle-cell anemia in mouse models. Earlier this month, scientists from the University of North Carolina at Chapel Hill showed that mature human skin cells could be reprogrammed into cells that produce insulin, the hormone used to treat diabetes.

However, those earlier experiments share a key limitation: The reprogramming genes have to be transported into the cell with the help of retroviruses. While such viruses are good at penetrating cells, they also integrate into the cellular DNA and can cause cancer or other unwanted genetic changes.

Now, there may be a way around that problem. In the latest mouse study, published in the journal Science, researchers show that by using a different kind of transport vehicle -- an adenovirus -- it is possible to avoid the permanent genetic damage seen in previous experiments.

"The adenovirus doesn't integrate permanently, so the cells aren't altered genetically," said Konrad Hochedlinger, geneticist at Harvard Stem Cell Institute in Cambridge, Mass., and lead author of the paper.

There is still a lot of work to be done. The same experiment has to be shown to work with human cells, and its efficiency has to be improved. Previous tests using retroviruses showed that only one in 1,000 adult cells got reprogrammed and turned into an embryonic-like cell. The latest experiment using adenovirus showed an even lower efficiency rate: Only one in 10,000 to one in 100,000 adult cells got reprogrammed.

While the latest advances have spurred a rush to improve the reprogramming technique, they have also given fresh ammunition to those who oppose research on human embryos, an alternative technique.

Earlier this week, the International Society for Stem Cell Research issued an "open letter" calling for the U.S. government to fund all avenues of research. The letter noted that while reprogramming had "captured the imagination" of scientists everywhere, research on human embryonic cells shouldn't be abandoned.

Write to Gautam Naik at gautam.naik@wsj.com

Negotiating a Bail-out Deal with DC??

WASHINGTON -- The Bush administration and Congress closed in on a new compromise aimed at stabilizing U.S. financial markets, a move designed to assuage conservatives who one day earlier had staged a revolt against the controversial $700 billion project.

The potential compromise isn't yet final, and details could change. But as of Friday night it appears that the plan's central elements, as originally envisioned by the Treasury Department, remain intact.


Associated Press
Senate Banking Committee Chairman Dodd, center, standing with House Financial Services Committee Chairman Frank and Sen. Schumer.
Congressional leaders were planning for possible votes Sunday.

The renewed effort represents a remarkable turnaround from the fracas that engulfed Washington Thursday night. In a sign of the political tensions at play, an earlier compromise plan was thrown into disarray after a White House meeting of top leaders -- including the two presidential candidates -- descended into a shouting match.

Republican nominee Sen. John McCain had returned to Washington to attend bailout negotiations. But the interjection of the presidential campaign, and the resulting finger-pointing, upset the delicate balance that had been struck in negotiations between congressional Democrats and Treasury Secretary Henry Paulson.

"I would hope the two presidentials would go to the debate tonight and leave us alone to get our work done here," said Sen. Harry Reid, a Nevada Democrat, sounding exhausted on the Senate floor Friday morning.

Under the Bush plan, the Treasury Department would be able to buy $700 billion of toxic investments currently burdening many financial institutions. The hope is that doing so would encourage investors to recapitalize the struggling banks, and get the nation's bond markets working again.

It would also, however, put taxpayers on the hook for potential losses if the investments bought by the government didn't later recover some of their value.

House Republicans, antsy about the power granted to the Treasury under that original plan, wanted to replace it with one based on an insurance model: Banks would pay premiums into a pool of money that would then be used to cover losses on the bad assets in question.

Treasury officials had earlier told lawmakers the concept was unworkable, people familiar with the matter said. Indeed, officials there briefly considered it, but concluded it wouldn't be as effective in clearing the rot from banks' balance sheets.

The compromise being hammered out Friday night would graft the insurance concept onto the original Treasury plan, most likely as an option. That would satisfy the administration, which could chose not to use it, as well as conservative lawmakers, who can claim to have influenced the legislation.

The White House has already agreed to other Democratic demands for the bailout, including greater oversight of the plan, and pay curbs for executives at some companies that benefit from the bailout.

The administration also agreed to a commitment to help struggling homeowners. And it agreed for the $700 billion to be released in installments; $250 billion would be made available immediately.

As Friday unfolded, Democrats signaled a willingness to consider including some version of the insurance proposal. "Adding insurance as an option...that's never been an issue," said Rep. Barney Frank (D., Mass.), chairman of the House Financial Services Committee and a lead negotiator.

At a late-afternoon news conference, House Speaker Nancy Pelosi sounded conciliatory, suggesting that Mr. Paulson should have "the latitude to accept any and all proposals," so long as they don't interfere with the core goals of the bailout plan.

The unexpected opposition from House Republicans on Thursday had thrown into chaos efforts to craft a rescue package for the financial markets. Democratic leaders of the House and Senate, after working with the Bush White House for several days on details, said they felt blindsided by the Republican move.

The face-off reflected years of tension between the Bush White House and House Republicans, and exposed the ideological differences within the Republican Party over the role of government in free markets.

President George W. Bush, who urged lawmakers to "rise to the occasion" Friday, has said his first instinct is to not intervene in the market. But he became convinced of the need after Mr. Paulson and Federal Reserve Chairman Ben Bernanke warned that the financial crisis could spread to Main Street from Wall Street and throw the country into a deep recession.

Many Senate Republicans, including Bob Bennett of Utah and Judd Gregg of New Hampshire, have tried to be supportive of the White House's efforts to find common ground with Democrats. But conservatives who dominate the Republican Party's caucus in the House have been less amenable, particularly those disaffected with the Bush administration's sizable domestic spending and the realities of life as a minority party.

Rep. Tom Davis (R., Va.) said Republicans have felt like "bystanders" the past two years and wanted to be brought into the negotiations as full partners. Democrats "have got to come and meet us halfway," he said.

By midweek, it became clear that only a couple dozen of the 199 House Republicans were likely to support the plan in its existing form.

House Republicans say their alternative proposal would bring stability and new capital to the market. It would also remove regulatory barriers that they say block private investors from investing capital into ailing financial institutions.

"We were simply trying to come up with a constructive solution to break an impasse," said Rep. Paul Ryan (R., Wis.), who outlined the plan to Sen. McCain in a meeting Thursday.

The struggle over the bailout bill represents one of the most dramatic congressional showdowns of recent years. In 1990, the Democratic House voted down a major deficit-reduction package backed by the administration of the first President Bush. The package was later brought back to the floor and approved, but only after changes that tilted the measure to the left.

A few years later, the Republican-controlled Congress balked at the Clinton administration's plans to help rescue Mexico's economy, forcing the administration to use other measures to achieve its goals.

At a closed-door meeting of House Republicans on Friday, House Minority Leader John Boehner and other party leaders received an ovation for having resisted pressure to support the Bush-backed package during a White House meeting the previous day.

Write to Greg Hitt at greg.hitt@wsj.com, Sarah Lueck at sarah.lueck@wsj.com and Deborah Solomon at deborah.solomon@wsj.com
Today's Top Story

Researchers develop safer method to create stem cells
U.S. scientists used an adenovirus to deliver four transformative genes -- Oct4, Sox2, Klf4 and c-Myc -- into ordinary mouse cells to produce induced pluripotent stem cells, which appear and behave like embyronic stem cells. Because the technique does not use retroviruses that may trigger tumors, it could lead to a safer way of testing cell treatments for sickle cell anemia, Parkinson's disease and other disorders, the study's lead author said. Yahoo!/Reuters (9/25) , The Wall Street Journal (subscription required) (9/25)


Bioengineered pigs could aid research on cystic fibrosis
U.S. scientists have genetically engineered piglets to have the same mutation that causes cystic fibrosis. Since pigs' lungs share many qualities with human lungs, the scientists hope to gain a better understanding of how the disease develops and how it can be treated in people. Reuters (9/25).

Calif. stem cell institute to devise appeal process for grant requests
The California Institute for Regenerative Medicine's board was scheduled to meet Thursday to consider developing a unified appeal process that scientists can use to ask for reviews of denied grant applications. The board hopes to develop an appeals process that creates "some order from something that could become disorderly and unreasonable," said Alan Trounson, the institute's president. San Diego Union-Tribune (9/25)
Study: Flu vaccine delivered into lungs is more efficient, cost-effective
Australian researchers found that lower doses of a flu vaccine delivered directly into the lungs of sheep provided stronger immune response than the higher, standard injected dose. The finding suggests that lung delivery could provide improved protection and allow more people to have access to the vaccine because of lower doses, a researcher said. Reuters (9/25)


Performance Management: The Future of Medical Device Manufacturing
In the face of competition, regulation and customer demands, Medical Device manufacturers must confront operational challenges that impact the top and bottom line. Click Here for a free white paper and learn how the leading companies leverage their best of breed systems for optimal productivity.


Company & Financial News
Prices of costly specialty drugs continue to rise
Figures released by AARP show that the wholesale cost of specialty medicines, which are used to treat cancer and other complex diseases, went up last year by 8.7% -- three times the rate of U.S. inflation. The rising costs are "increasing the burden on people with chronic conditions who can least afford it," an AARP official said. The Pharmaceutical Research and Manufacturers of America did not immediately respond to a request for comment on the report.


Ligand to acquire Pharmacopeia in stock deal
Ligand Pharmaceuticals announced that it will purchase biotech firm Pharmacopeia in a stock transaction worth as much as $70 million. The deal will help Ligand bolster its product pipeline and drug-discovery capabilities and is expected to be finalized in the first quarter of 2009. The Star-Ledger (Newark, N.J.) (9/26) , Reuters (9/24) , San Diego Business Journal (9/24).

UCB withdraws EU application for expanded use of Vimpat
The European Medicines Agency's negative review of Vimpat's use in diabetic neuropathic pain has prompted UCB to drop its EU application for the expanded use of the epilepsy treatment. A UCB spokeswoman said the Belgian drugmaker plans to conduct an additional clinical study "to further substantiate the magnitude" of Vimpat's effects in patients with diabetic neuropathic pain. Reuters (9/25)
Arca Biopharma reaches merger deal with Nuvelo.

Arca Biopharma is set to merge with Nuvelo under a deal that is expected to be finalized early next year. The move comes after the FDA agreed to review Arca's Gencaro, a treatment for heart failure. "This unique transaction offers us the financial resources, people and pipeline as we continue to build our company," Arca President and CEO Richard Brewer said. American City Business Journals/Denver (9/25)
Other News
Expert: Alabama companies must take advantage of BIO conference
American City Business Journals/Birmingham, Ala. (9/25)

Food & Agriculture.
Biotech cotton could mean surge in crop in India, official says
Cotton production in India is expected to go up by 4.8% in 2009, driven by the increased use of biotech crops and favorable climatic conditions, said the country's textiles commissioner, A.B. Joshi. High cotton yields could raise exports to countries such as China but further weaken prices, which have declined by 10% in New York this year. Bloomberg (9/25)

Industrial & Environmental.
PGE, Columbia Energy will feed algae with CO2 to make biofuel
Portland General Electric aims to generate biofuel by using carbon dioxide emissions from one of its facilities to grow algae in a collaborative effort with Columbia Energy Partners. The companies plan to use oil extracted from mature algae to make biodiesel and livestock feed. The Oregonian (Portland) (9/26)


--Franklin D. Roosevelt,
32nd U.S. president

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Tuesday, September 23, 2008

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Monday, September 22, 2008

Biomedical Research Videos

Bright Minds. Produced by Rex Barnett. Atlanta: History on Video, 2001.
Audience Level: Grades 10 and above
Description: Three African-American students, interviewed at the Student National Medical Association's annual conference in Atlanta in April, 2001, comment on their preparation for and experiences during medical training, and share advice on succeeding in medical school. J. Nadine Gracia, President of the Student National Medical Association, the oldest and largest student organization for minority students in the United States, emphasizes the importance of mentorship to the future of minority medical education.
Careers in Medicine: Physician. Princeton: Films for the Humanities & Sciences, 1998.
Audience Level: Grades 9-12
Description: This video offers high school students interested in medicine a good overview of the profession, based on vignettes and short interviews of medical school students, instructors, and those working in the field both in clinical and academic settings. Those interviewed discuss what it takes to succeed in medicine, ways to gain practical volunteer experience in the health fields, strategies for finding mentors and for obtaining course planning advice, the current atmosphere of recruiting for minorities and women, how to find funding for a medical education, what medical school is like, and the criteria for evaluating medical school applicants. The emphasis of this video is on the planning needed to prepare for medical school and the self-discipline needed to succeed once in medical school.
Making the Grade: From Med School to Internship. Part of the "Hopkins 24/7: Inside America's Best Hospital System" series. Produced by ABC News. Princeton: Films for the Humanities & Sciences, 2001.
Audience Level: Grades 10 and above
Description: Johns Hopkins University School of Medicine students from the first year to the fourth year comment on various aspects of their medical training, from their anticipation of the first day in the anatomy laboratory and being directly responsible for patient care, to their anxieties about future internships and coping with the real world burdens of the health care system. This video is similar in format to the first of the Harvard Medical School series (So You Want to Be a Doctor?) that follows seven students over a period of fourteen years, but does not have the same level of intimacy or depth. Overall, this is an attractive, well-made, and enjoyable video that will give prospective medical students a insider's perspective on the rigors of medical training.
Making of a Doctor. Written, produced, and directed by Michael Barnes. A NOVA production by the WGBH/Boston Science Unit. Boston: WGBH Educational Foundation, 1995.
Audience Level: Grades 10 and above
Description: This is the second installation in a three-part series that follows seven Harvard Medical School students over a period of fourteen years, from their medical school training to the beginnings of their professional careers. The first hour of this video is designed so that viewers who have not seen So You Want to be a Doctor will get a coherent narrative, thus basically reiterating many of the key scenes from part one. After showing scenes from medical school graduation, the second hour goes on to follow these newly minted MDs as they continue in their individual directions in internship and residency programs. This second video, like its predecessor, is marked by clear and well-paced narration, a sense of drama, and overall excellence in storytelling and video quality. As in the first, the sense of intimacy is well captured. Highly recommended for high school and college audiences.
So You Want to Be a Doctor? Written, produced, and directed by Michael Barnes. A NOVA production by the WGBH/Boston Science Unit. Boston: WGBH Educational Foundation, 1991. Princeton: Films for the Humanities & Sciences, 1991.
Audience Level: Grades 10 and above
Description: Narrated by actor Neil Patrick Harris, star of the TV series Doogie Howser, M.D., this is the first of three videos in a series that follows seven Harvard Medical School students over a period of fourteen years. This video covers the four years of medical school and takes its audience into the many firsts of young doctors in training, among them the first cadaver dissection, the first patient exam, and the first death. Scenes from the lives of the seven students reveal the hardships, rewards, and drama of this test of endurance. The students and their parents, partners, and teachers speak intimately about the impact of medical school on these students. This is an excellent video that provides a fascinating and personal view of medical training, while balancing a dramatic narrative with integrity.
Survivor MD. Written, produced, and directed by Michael Barnes. A NOVA production by the WGBH/Boston Science Unit. Boston: WGBH Educational Founation, 2001.
Audience Level: Grades 10 and above
Description: This video wraps up the three-part documentary series that follows seven Harvard Medical School students over the course of fourteen years. Like the second video in the series, Survivor MD includes significant footage from the first, allowing new viewers to get acquainted with the background. This video concentrates mainly on the early careers of the seven characters.
Women Are Pathologists. National Institutes of Health Office of Research on Women's Health, and National Institutes of Health Office of Science Education. Bethesda: National Institutes of Health, 1999.
Audience Level: Grades 6-9
Description: In the first fictional section of this two-part video, a teenage girl learns about the field of pathology as she deals with the discovery of her sister's cervical cancer. In the second half of the video, three pathologists, Deborah Powell (asurgical pathologist), Maria Merino (an academic pathologist), and Mary Case (a clinical pathologist) give overviews of their roles within this medical specialty and the rewards and challenges of their positions. With an introduction by Victoria Powell, who plays Dr. Amanda Bentley on the TV series Diagnosis Murder, this is an engaging video that skillfully combines story and teaching. This video is part of a three-video series titled Women are Scientists, produced by the National Institutes of Health, and is available for free online by ordering at http://Science-Education.nih.gov.
Women Are Researchers. National Institutes of Health Office of Research on Women's Health, National Institutes of Health Office of Science Education and Association of Women Surgeons. Bethesda: National Institutes of Health, 2000.
Audience Level: Grades 5-7
Description: With an introduction by Gates McFadden, from the TV series Star Trek: The Next Generation, this entertaining and vibrant video features short vignettes organized around questions posed by the young hostess of this show. Viewers are given a short history of women in medicine and a research problem involving the hypothesis that "science is fun." Three researchers in different settings, Terry Young, Connie Noguchi, and Judith Pachciarz talk about overcoming gender, ethnic, and physical barriers to achieve success in their profession. Their discussion ranges from their passion for research and balancing personal and professional lives, to giving valuable advice to young women (grades 5 to 7), to planning for a biomedical research career. This video is part of a three-video series titled Women are Scientists, produced by the National Institutes of Health, and is available for free online by ordering at http://Science-Education.nih.gov.
Women Are Surgeons. National Institutes of Health Office of Research on Women's Health, National Institutes of Health Office of Science Education, and Association of Women Surgeons. Bethesda: National Institutes of Health, 1998.
Audience Level: Grades 5-7
Description: This video introduces young women to the professional and personal lives of three women surgeons, thoracic surgeon Victoria Stevens, cardiac surgeon Rosalyn Sterling-Scott, and trauma surgeon Yvette LaClaustra. Women are Surgeons features a series of short scenes showing the real life drama of these women at work. Various young adults pose questions of interest to them, such as, "How do you make time for life outside of work?" and "How do you deal with stress?" which the three surgeons take turns answering. With an introduction by Christine Lahti, Emmy Award winning actress from Chicago Hope, this video provides a lively and appealing way of encouraging young women grades 5 to 7 to pursue careers in surgery. This video is part of a three-video series titled Women are Scientists, produced by the National Institutes of Health, and is available for free online by ordering at http://Science-Education.nih.gov.
Women in Medicine. A production of Dartmouth/Hitchcock Medical Center. Princeton: Films for the Humanities & Sciences, 1993.
Audience Level: Grades 10 and above
Description: This informative video starts with scenes from a 1930s newsreel, Men of Medicine, as a contrast to its own discussion about the likely changes that will occur as women continue to contribute to the field of medicine. Some of the questions and issues raised are the emerging changes in research and patient care, with women contributing widely to medicine and the possibility of women bringing new skills into the profession. Various physicians and educators comment on the lives of medical women and their impact on this field.


Biomedical Research Bibiography

Abram, Ruth, ed. Send Us a Lady Physician: Women Doctors in America, 1835-1920. New York: Norton, 1985.
Apple, Rima, ed. Women, Health, and Medicine in America: A Historical Handbook. New York: Garland, 1990.
Bickel, Janet. Women in Medicine. Thousand Oaks, CA: Sage Publications, 2000.
Bickel, Janet, and Delese Wear, eds. Educating for Professionalism: Creating a Culture of Humanism in Medical Education. Iowa City: University of Iowa Press, 2000.
Bleier, Ruth, ed. Feminist Approaches to Science. New York: Pergamon Press, 1986.
Bleier, Ruth. Gender and Science: A Critique of Biology and its Theories on Women. New York: Pergamon Press, 1984.
Bonner, Thomas Neville. To the Ends of the Earth: Women's Search for Education in Medicine. Cambridge, MA: Harvard University Press, 1992.
Borst, Charlotte. Catching Babies: The Professionalization of Childbirth 1870-1920. Cambridge, MA: Harvard University Press, 1995.
Bowman, Marjorie and Deborah I. Allen. Stress and Women Physicians. New York: Springer-Verlag, 1985.
Bowman, Marjorie, Erica Frank, and Deborah Allen. Women in Medicine: Career and Life Management. rev. ed. of Stress and Women Physicians. New York: Springer-Verlag, 2002.
Campbell, Margaret A. [Mary Howell]. Why Would a Girl Go Into Medicine? Medical Education in the United States: A Guide for Women. Old Westbury, NY: The Feminist Press, 1973.
Candib, Lucy. Medicine and the Family. New York: Basic Books, 1995.
Cassell, Joan. The Woman in the Surgeon's Body. Cambridge, MA: Harvard University Press, 1997.
Chaff, Sandra, Ruth Haimbach, Carol Fenichel, and Nina Woodside, eds. Women in Medicine: a Bibliography of the Literature on Women Physicians. Metuchen, NJ: Scarecrow Press, 1977.
Chen, Eliza Lo, ed. This Side of Doctoring: Reflections from Women in Medicine. Thousand Oaks, CA: Sage Publications, 2002.
Conley, Frances K. Walking Out On the Boys. New York: Farrar, Straus and Giroux, 1998.
Dawson, Patricia L. Forged by the Knife: The Experience of Surgical Residency from the Perspective of a Woman of Color. Seattle: Open Hand Publications, 1999.
Dickstein, Leah J. and Carol C. Nadelson, ed. Women Physicians in Leadership Roles. Washington, DC: American Psychiatric Press, 1986.
Drachman, Virginia. Hospital with a Heart: Women Doctors and the Paradox of Separatism at the New England Hospital 1862-1969. Ithaca: Cornell UniversityPress, 1984.
Furst, Lilian R., ed. Women Physicians and Healers: Climbing a Long Hill. Lexington, KY: University Press of Kentucky, 1998.
Glazer, Penina M. and Miriam Slater.Unequal Colleagues: The Entry of Women into the Professions 1890-1940. New Brunswick, NJ: Rutgers University Press, 1987.
Hine, Darlene Clark, Elsa Barkley Brown, and Rosalyn Terborg-Penn, eds. Black women in America: An Historical Encyclopedia. 2 Vols. Bloomington: Indiana University Press, 1994.
Hurd-Mead, Kate Campbell. A History of Women in Medicine: From the Earliest Times to the Beginning of the Nineteenth Century. Boston: Milford House, 1973.
Hornstein, Gail A. To Redeem One Person is to Redeem the World: The Life of Frieda Fromm-Reichman. New York: Free Press, 2000.
Klass, Perri. A Not Entirely Benign Procedure: Four Years as a Medical Student. New York: Putnam, 1987.
Klass, Perri. Baby Doctor: A Pediatrician's Training. New York: Random House, 1992.
Klass, Perri. Taking Care of Your Own: Parenthood and the Medical Mind. Knoxville, TN: Whittle Direct Books, 1992.
Klass, Perri. Love and Modern Medicine: Stories. Boston: Houghton Mifflin Company, 2001.
Klass, Perri. Other Women's Children. New York: Random House, 1990.
Ko, Kathryn. The Survival Bible for Women in Medicine. New York: Parthenon Publishing Group, 1998.
Leavitt, Judith Walzer. Women and Health in America. Madison, WI: University of Wisconsin Press, 1999.
Lightfoot, Sarah Lawrence. Balm in Gilead: Journey of a Healer. Reading, MA: Addison-Wesley Publishing Co., 1988.
Lopate, Carol. Women in Medicine. Baltimore: Johns Hopkins Press, 1968.
Lorber, Judith. Women Physicians: Career, Status and Power. New York: Tavistock Publications, 1984.
Lovejoy, Esther Pohl. Certain Samaritans. New York: The Macmillan Company, 1927.
Lovejoy, Esther Pohl. Women Physicians and Surgeons. Livington, NY: Livingston Press, 1939.
Lovejoy, Esther Pohl. Women Physicians of the World. New York: Macmillan, 1957.
Moldow, Gloria M. Women Doctors in Gilded-Age Washington: Race, Gender, and Professionalism. Urbana, IL: University of Illinois Press, 1987.
Morantz-Sanchez, Regina Markell, Sympathy and Science: Women Physicians in American Medicine. New York: Oxford University Press, 1985.
Morantz-Sanchez, Regina Markell. Conduct Unbecoming a Woman: Medicine on Trial in Turn-of-the-Century Brooklyn. New York: Oxford University Press, 2000.
Morantz-Sanchez, Regina Markell, Cynthia Stodola Pomerleau and Carol Hanson Finichel, eds. In Her Own Words: Oral Histories of Women Physicians. Westport, CT: Greenwood Press, 1982.
More, Ellen S. Restoring the Balance: Women Physicians and the Profession of Medicine, 1850-1995. Cambridge, MA: Harvard University Press, 1999.
More, Ellen S. Maureen A. Milligan, ed., The Empathic Practitioner: Empathy, Gender, and Medicine. New Brunswick, NJ: Rutgers University Press, 1994.
Notable American Women 1607-1950. Cambridge, MA: Belknap Press of Harvard University Press, 1971.
Notable American Women: The Modern Period.Cambridge: Belknap Press of Harvard University Press, 1980.
Peitzman, Stephen J. A New and Untried Course: Women's Medical College and Medical College of Pennsylvania 1850-1998. New Brunswick, NJ: Rutgers University Press, 2000.
Perrone, Bobette, and H. Henrietta Stockel and Victoria Krueger. Medicine, Curanderas, and Women Doctors. Norman: University of Oklahoma Press, 1989.
Remen, Rachel Naomi. Kitchen Table Wisdom: Stories That Heal. New York: Riverhead Books, 1996.
Remen, Rachel Naomi. My Grandfather's Blessings: Stories of Strenth, Refuge and Belonging. New York: Riverhead Books, 2000.
Sicherman, Barbara. Alice Hamilton, A Life in Letters. Cambridge, MA: Harvard University Press, 1984.
Smith, Susan L. Sick and Tired of Being Sick and Tired. Philadelphia: University of Pennsylvania Press, 1995.
Stepansky, Paul E. compiler & ed. The Memoirs of Margaret S. Mahler. New York: Free Press, 1988; London: Collier Macmillan, 1988.
Tong, Benson. Susan LaFlesche Picotte: Omaha Indian Leader and Reformer. Norman: University of Oklahoma Press, 1999.
Truax, Rhoda. The Doctors Jacobi. Boston: Little, Brown, 1952.
Vietor, Agnes C, ed. A Woman's Quest: The Life of Marie E. Zakrzewska, M.D. New York: Arno Press, 1972.
Walsh, Mary Roth. "Doctors Wanted: No Women Need Apply": Sexual Barriers in the Medical Profession, 1835-1975. New Haven: Yale University Press, 1977.
Wear, Delese, ed. Women in Medical Education: An Anthology of Experience. New York: State University of New York Press, 1996.
Wells, Susan. Out of the Dead House: Nineteenth-Century Women Physicians and the Writing of Medicine. Madison, WI: University of Wisconsin, 2001.

Suggested Medicine by NIH: Tomorrow medicine-Books

Baldwin, Joyce. To Heal the Heart of a Child: Helen Taussig, M.D. New York: Walker and Company, 1992.
Reading Level: Grades 5-7
Featured Physicians: Helen Taussig
Bel Monte, Kathryn I. African-American Heroes & Heroines: 150 True Stories of African-American Heroism. Illustrated by Kathryn I. Bel Monte. Hollywood: Lifetime Books, Inc., 1998.
Reading Level: Grades 6-8
Featured Physicians: Rebecca Crumpler, Mae Jemison
Bolden, Tonya. And Not Afraid to Dare: The Stories of Ten African-American Women. New York: Scholastic Press, 1998.
Reading Level: Grades 4-7
Featured Physicians: Mae Jemison
Bortstein, Larry. After Olympic Glory: The Lives of Ten Outstanding Medalists. New York: Frederick Warne, 1978.
Reading Level: Grades 4-7
Featured Physicians: Tenley Albright
Bowman, Kathleen. New Women in Medicine. Mankato: Creative Educational Society, Inc., 1976.
Reading Level: Grades 4-6
Featured Physicians: Mary Calderone, Elisabeth Kübler-Ross
Brew, Lydia E. The Story of Edith Irby Jones, M.D. N.p., 1986.
Reading Level: Grades 5-7
Featured Physicians: Edith Irby Jones
Brown, Jordan. Elizabeth Blackwell. American Women of Achievement. New York: Chelsea House Publishers, 1989.
Reading Level: Grades 6-9
Featured Physicians: Elizabeth Blackwell
Brown, Marion Marsh. Homeward the Arrow's Flight. Nashville: Abingdon, 1980.
Reading Level: Grades 5-7
Featured Physicians: Susan Picotte
Butts, Ellen R., and Joyce R. Schwartz. May Chinn: The Best Medicine. New York: W.H. Freeman and Company, 1995.
Reading Level: Grades 4-6
Featured Physicians: May Chinn
Campbell, Robin. Florence Sabin: Scientist. New York: Chelsea House Publishers, 1995.
Reading Level: Grades 3-6
Featured Physicians: Florence Sabin
Clapp, Patricia. Dr. Elizabeth: A Biography of the First Woman Doctor. New York: Lothrop, Lee & Shepard Co., 1974.
Reading Level: Grades 7-12
Featured Physicians: Elizabeth Blackwell
Cox, Clinton. African American Healers. New York: John Wiley & Sons, Inc., 2000.
Reading Level: Grades 5-7
Featured Physicians: Rebecca Crumpler, M. Jocelyn Elders, Justina Ford, Deborah Prothrow-Stith
Curtis, Robert H. Medicine: Great Lives. New York: Charles Scribner's Sons, 1993.
Reading Level: Grades 5-8
Featured Physicians: Elizabeth Blackwell, Helen Taussig
Dunnahoo, Terry. Emily Dunning: A Portrait. Chicago: Reilly & Lee Books, 1970.
Reading Level:Grades 5-8
Featured Physicians: Emily Barringer
Epps, Charles H. Jr., Davis G. Johnson, and Audrey L. Vaughan. African-American Medical Pioneers. Rockville: Betz Publishing Company, 1994.
Reading Level: Grades 7-10
Featured Physicians: Helen Dickens, Roselyn Epps, Gertrude Hunter, Renee Jenkins, Audrey Manley, Vivian Pinn, Deborah Prothrow-Stith, M. Jeanne Spurlock
Ferris, Jeri. Native American Doctor: The Story of Susan La Flesche Picotte. Minneapolis: Carolrhoda Books, Inc., 1991.
Reading Level: Grades 4-7
Featured Physicians: Susan Picotte
Garza, Hedda. Women in Medicine. New York: Franklin Watts, 1994.
Reading Level: Grades 11 and above
Featured Physicians: Elizabeth Blackwell, Emily Blackwell, Rebecca Cole, Rebecca Crumpler, Matilda Evans, Vanessa Gamble, Alice Hamilton, Catherine Howell, Mary Jacobi, Halle Johnson, Ann Preston, Florence Sabin, Helen Taussig, Mary Walker, Marie Zakrzewska
Glimm, Adele. Elizabeth Blackwell: First Woman Doctor of Modern Times. New York: McGraw-Hill, 2000.
Reading Level: Grades 3-7
Featured Physicians: Elizabeth Blackwell
Greene, Carol. Elizabeth Blackwell: First Woman Doctor. Chicago: Childrens Press, Inc., 1991.
Reading Level: Grades 1-3
Featured Physicians: Elizabeth Blackwell
Hansen, Joyce. Women of Hope: African Americans Who Made a Difference. Foreword by Moe Foner. New York: Scholastic Press, 1998.
Reading Level: Grades 4 and above
Featured Physicians: Alexa Canady, Mae Jemison
Hasday, Judy L. Extraordinary Women Athletes. New York: Childrens Press, 2000.
Reading Level: Grades 4-7
Featured Physicians: Tenley Albright
Hayden, Robert C. 11 African-American Doctors. Frederick: Twenty-First Century Books, 1992.
Reading Level: Grades 4-7
Featured Physicians: Jane Wright
Henry, Joanne Landers. Elizabeth Blackwell: Girl Doctor. New York: Aladdin Paperbacks, 1996.
Reading Level: Grades 2-5
Featured Physicians: Elizabeth Blackwell
Hume, Ruth Fox. Great Women of Medicine. New York: Random House, 1964.
Reading Level: Grades 7-12
Featured Physicians: Elizabeth Blackwell, Alice Hamilton, Mary Jacobi, Florence Sabin
Hunter, Shaun. Leaders in Medicine. New York: Crabtree Publishing Company, 1999.
Reading Level: Grades 3-5
Featured Physicians: Dorothy Andersen, Virginia Apgar, S. Josephine Baker, Gerti Cori, Alice Hamilton, Mae Jemison, Elisabeth Kübler-Ross, Antonia Novello, Helen Taussig, Florence Sabin
Jemison, Mae C. Find Where the Wind Goes: Moments From My Life. New York: Scholastic Press, 2001.
Reading Level: Grades 4-7
Featured Physicians: Mae Jemison
Kaye, Judith. The Life of Florence Sabin. New York: Twenty-First Century Books, 1993.
Reading Level: Grades 4-7
Featured Physicians: Florence Sabin
Kent, Jacqueline C. Women in Medicine. Minneapolis: The Oliver Press, Inc., 1998.
Reading Level: Grades 5-8
Featured Physicians: Virginia Apgar, Elizabeth Blackwell, Dorothy Brown, May Chinn, Alma Morani, Susan Picotte, Helen Taussig, Mary Walker
Klass, Perri. A Not Entirely Benign Procedure: Four Years As a Medical Student. New York: G.P. Putnam's Sons, 1987.
Reading Level: Grades 10 and above
Featured Physicians: Perri Klass
Kline, Nancy. Elizabeth Blackwell: A Doctor's Triumph. Berkeley: Conari Press, 1997.
Reading Level: Grades 5-8
Featured Physicians: Elizabeth Blackwell
Krapp, Kristine, ed. Notable Black American Scientists. Detroit: Gale, 1999.
Reading Level: Grades 10-12
Featured Physicians: Dorothy Brown, Rebecca Cole, Rebecca Crumpler, M. Jocelyn Elders, Matilda Evans, Dorothy Ferebee, Mae Jemison, Halle Johnson, Edith Irby Jones, Margaret Lawrence, M. Jeanne Spurlock, Jane Wright
Kronstadt, Janet. Florence Sabin: Medical Researcher. New York: Chelsea House Publishers, 1990.
Reading Level: Grades 6-9
Featured Physicians: Florence Sabin
Lindrop, Laurie. Scientists and Doctors. New York: Twenty-First Century Books, 1997.
Reading Level: Grades 6-9
Featured Physicians: Mae Jemison, Susan Love, Helen Taussig
Lyman, Darryl. Great African American Women. New York: Gramercy Books, 1999.
Reading Level: Grades 7-12
Featured Physicians: Mae Jemison
McClure, Judy. Healers and Researchers: Physicians, Biologists, Social Scientists. Austin: Raintree Steck-Vaughn Publishers, 2000.
Reading Level: Grades 4-6
Featured Physicians: Maude Abott, Hattie Alexander, Dorothy Andersen, Virginia Apgar, S. Josephine Baker, Elizabeth Blackwell, Emily Blackwell, May Chinn, Rebecca Cole, Gerti Cori, M. Jocelyn Elders, Alice Hamilton, Mary Jacobi, Mae Jemison, Elisabeth Kubler-Ross, Susan Picotte, Dorothy Mendenhall, Rosa Minoka-Hill, Antonia Novello, Ann Preston, Florence Sabin, Helen Taussig, Bertha Van Hoosen, Mary Walker, Anna Williams, Jane Wright, Marie Zakrzewska
McKissack, Patricia, and Frederick McKissack. African-American Scientists. Brookfield: The Millbrook Press, 1994.
Reading Level: Grades 4-6
Featured Physicians: Rebecca Cole, Rebecca Crumpler, Mae Jemison
McLenighan, Valjean. Women and Science. Milwaukee: Raintree Publishers, 1979.
Reading Level: Grades 3-5
Featured Physicians: Alice Hamilton, Florence Sabin
McPherson, Stephanie Sammartino. The Workers' Detective: A Story About Dr. Alice Hamilton. Minneapolis: Carolrhoda Books, Inc., 1992.
Reading Level: Grades 3-6
Featured Physicians: Alice Hamilton
Morey, Janet Nomura, and Wendy Dunn. Famous Hispanic Americans. New York: Cobblehill Books, 1996.
Reading Level: Grades 4-6
Featured Physicians: Antonia Novello
Noble, Iris. The First Woman Ambulance Surgeon. New York: Julian Messner, Inc., 1962.
Reading Level: Grades 6-9
Featured Physicians: Emily Barringer
Phelan, Mary Kay. Probing the Unknown: The Story of Dr. Florence Sabin. New York: Thomas Y. Crowell Company, 1969.
Reading Level: Grades 5-8
Featured Physicians: Florence Sabin
Potter, Joan, and Constance Claytor. African Americans Who Were First. New York: Cobblehill Books, 1997.
Reading Level: Grades 4-6
Featured Physicians: Rebecca Crumpler, Mae Jemison
Ptacek, Greg. Champion for Children's Health. Minneapolis: Carolrhoda Books, Inc., 1994.
Reading Level: Grades 3-6
Featured Physicians: S. Josephine Baker
Ranahan, Demerris C. Medicine. Minneapolis: Dillon Press, Inc., 1981.
Reading Level: Grades 5-8
Featured Physicians: Virginia Apgar, Adele Hofmann, Olga Jonasson, Elizabeth Blackwell, Mary Jacobi, Alice Hamilton, Susan Picotte, Helen Taussig, Jane Wright, Marie Zakrzewska
Redberg, Rita F., and Judith Love Cohen. You Can Be a Woman Cardiologist. Culver City: Cascade Press, Inc., 1996.
Reading Level: Grades 2-4
Featured Physicians: Rita Redberg
Sabin, Francene. Elizabeth Blackwell: The First Woman Doctor. Mahwah: Troll Associates, 1982.
Reading Level: Grades 2-4
Featured Physicians: Elizabeth Blackwell
Schleichert, Elizabeth. The Life of Elizabeth Blackwell. Frederick: Twenty-First Century Books, 1992.
Reading Level: Grades 4-7
Featured Physicians: Elizabeth Blackwell
Sinnott, Susan. Extraordinary Hispanic Americans. Chicago: Childrens Press, 1991.
Reading Level: Grades 4-6
Featured Physicians: Antonia Novello
Steelsmith, Shari. Elizabeth Blackwell: The Story of the First Woman Doctor. Seattle: Parenting Press, Inc., 1987.
Reading Level: Grades K-3
Featured Physicians: Elizabeth Blackwell
Stille, Darlene R. Extraordinary Women of Medicine. New York: Children's Press, 1997.
Reading Level: Grades 5-9
Featured Physicians: Hattie Alexander, Dorothy Andersen, S. Josephine Baker, Elizabeth Blackwell, Emily Blackwell, Emeline Cleveland, Alice Hamilton, Bernadine Healy, Mary Jacobi, Elisabeth Kubler-Ross, Elise L'Esperance, Hannah Longshore, Esther Lovejoy, Anita McGee, Rosa Minoka-Hill, Antonia Novello, Susan Picotte, Ann Preston, Helen Taussig, Bertha Van Hoosen, Mary Walker, Jane Wright, Marie Zakrzewska
Stille, Darlene R. Extraordinary Women Scientists. Chicago: Childrens Press, 1995.
Reading Level: Grades 5-9
Featured Physicians: Gerti Cori, Mae Jemison, Florence Sabin
Sullivan, Otha Richard. African American Inventors. New York: John Wiley & Sons, Inc., 1998.
Reading Level: Grades 5-7
Featured Physicians: Jane Wright
Vare, Ethlie Ann, and Greg Ptacek. Women Inventors & Their Discoveries. Minneapolis: The Oliver Press, Inc., 1993.
Reading Level: Grades 4-7
Featured Physicians: S. Josephine Baker
Verheyden-Hilliard, Mary Ellen. Scientist and Physician: Judith Pachciarz. Bethesda: The Equity Institute, 1988.
Reading Level: Grades 2-3
Featured Physicians: Judith Pachchiarz
Wilkerson, J. L. A Doctor to Her People: Dr. Susan La Flesche Picotte. Kansas City: Acorn Books, 1999.
Reading Level: Grades 3-6
Featured Physicians: Susan Picotte